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Enter your email address below and we will send you your username Email or Customer ID Close If the address matches an existing account you will receive an email with instructions to retrieve your username COVID-19 Notice: How we support scientific communication and options for remote access to subscribed content JOURNALS EMBO Reports Molecular Systems Biology EMBO Molecular Medicine Life Science Alliance This Journal Anywhere Search journal Search Search EMBO Press Search Advanced search Citation search Login Close Drawer Menu Open Drawer Menu Menu JOURNALS Skip main navigation Close Drawer Menu Open Drawer Menu Menu Current Issue About Aims & Scope Editors & Board EMBO Press Policies Open Access Licenses & Charges Journal Indicators Contact Editorial Office Information For Authors For Reviewers For Librarians/Subscribers For Media For Advertisers Archive Alerts Submit CURRENT ISSUE The fastest Rubisco in nature By Dan Davidi, Melina Shamshoum, Zhijun Guo, Ron Milo and colleagues Crystal structure and biochemical analysis explains the specificity of SARS‐CoV‐2 PLpro for ISG15 and longer Lys48‐linked ubiquitin chains leading to the identification of inhibitors that show promising antiviral activity in a SARS‐CoV‐2 infection model. Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2 Theresa Klemm Gregor Ebert Dale J Calleja Cody C Allison Lachlan W Richardson Jonathan P Bernardini Bernadine GC Lu Nathan W Kuchel Christoph Grohmann Yuri Shibata Zhong Yan Gan James P Cooney Marcel Doerflinger Amanda E Au Timothy R Blackmore Gerbrand J van der Heden van Noort Paul P Geurink Huib Ovaa Janet Newman Alan Riboldi‐Tunnicliffe Peter E Czabotar Jeffrey P Mitchell Rebecca Feltham Bernhard C Lechtenberg Kym N Lowes Grant Dewson Marc Pellegrini Guillaume Lessene David Komander Crystal structure and biochemical analysis explains the specificity of SARS‐CoV‐2 PLpro for ISG15 and longer Lys48‐linked ubiquitin chains leading to the identification of inhibitors that show promising antiviral activity in a SARS‐CoV‐2 infection model. Close Figure Viewer Browse All Figures Return to Figure Change zoom level Zoom in Zoom out Previous Figure Next Figure Caption Latest Online Current Issue Most Read Article 16 September 2020 OPEN ACCESS Clustering of strong replicators associated with active promoters is sufficient to establish an early‐replicating domain Caroline Brossas Anne‐Laure Valton Sergey V Venev Sabarinadh Chilaka Antonin Counillon Marc Laurent Coralie Goncalves Bénédicte Duriez Franck Picard Job Dekker Marie‐Noëlle Prioleau Two replicators carrying timing information can cooperate when located in proximity, and advance replication timing by forming higher‐order chromatin contacts with active “A” compartments. Article 16 September 2020 OPEN ACCESS Re‐equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction Chongkui Sun Kun Wang Amanda J Stock Yi Gong Tyler G Demarest Beimeng Yang Neelam Giri Lea Harrington Blanche P Alter Sharon A Savage Vilhelm A Bohr Yie Liu Decreased levels of the essential cofactor nicotinamide adenine dinucleotide (NAD) are causally linked to telomere shortening in mouse models and patients suffering from the telomere maintenance disorder, dyskeratosis congenita. Article 16 September 2020 OPEN ACCESS MSH2 shapes the meiotic crossover landscape in relation to interhomolog polymorphism in Arabidopsis Alexander R Blackwell Julia Dluzewska Maja Szymanska‐Lejman Stuart Desjardins Andrew J Tock Nadia Kbiri Christophe Lambing Emma J Lawrence Tomasz Bieluszewski Beth Rowan James D Higgins Piotr A Ziolkowski Ian R Henderson Sequencing of polymorphisms between homologous chromosomes in wild‐type and mutant plants reveals an unexpected pro‐crossover role of the mismatch repair protein MSH2 in regions of higher relative sequence diversity. Article 16 September 2020 OPEN ACCESS Negative regulation of NEMO signaling by the ubiquitin E3 ligase MARCH2 Kiramage Chathuranga Tae‐Hwan Kim Hyuncheol Lee Jun‐Seol Park Jae‐Hoon Kim Wijesinghe A Gayan Chathuranga Pathum Ekanayaka Youn Jung Choi Chul‐Ho Lee Chul‐Joong Kim Jae U Jung Jong‐Soo Lee MARCH2 interacts with the NF‐κB modulator NEMO and initiates its ubiquitin‐dependent degradation for homeostatic control of innate immune responses to viral and bacterial infection. Article 15 September 2020 OPEN ACCESS β‐catenin signaling modulates the tempo of dendritic growth of adult‐born hippocampal neurons Jana Heppt Marie‐Theres Wittmann Iris Schäffner Charlotte Billmann Jingzhong Zhang Daniela Vogt‐Weisenhorn Nilima Prakash Wolfgang Wurst Makoto Mark Taketo Dieter Chichung Lie Precise timing and strength of β‐catenin signaling determines correct functional integration of adult‐born neurons, implicating Wnt/β‐catenin activity as protective pathway against aging‐related deficits in adult neurogenesis. Article 15 September 2020 OPEN ACCESS IL‐2/IL‐7‐inducible factors pioneer the path to T cell differentiation in advance of lineage‐defining factors Sarah L Bevington Peter Keane Jake K Soley Saskia Tauch Dominika W Gajdasik Remi Fiancette Veronika Matei‐Rascu Claire M Willis David R Withers Peter N Cockerill Cytokine signaling is required to maintain chromatin accessibility at binding/regulatory sites for lineage‐determining transcription factors, giving it a more instructive and not just downstream role in T cell fate determination. Article 14 September 2020 EGFR‐mediated tyrosine phosphorylation of STING determines its trafficking route and cellular innate immunity functions Chenyao Wang Xin Wang Manoj Veleeparambil Patricia M Kessler Belinda Willard Saurabh Chattopadhyay Ganes C Sen A phospho‐switch governs trafficking of the interferon response stimulator STING from the ER to endosomes instead of autophagosomes, allowing it to bind and activate its effector IRF3. Article 14 September 2020 The tRNA pseudouridine synthase TruB1 regulates the maturation of let‐7 miRNA Ryota Kurimoto Tomoki Chiba Yoshiaki Ito Takahide Matsushima Yuki Yano Kohei Miyata Yuka Yashiro Tsutomu Suzuki Kozo Tomita Hiroshi Asahara TruB1 promotes let‐7 maturation independently of its enzymatic activity by enhancing the interaction of pri‐let‐7 and the microprocessor DGCR8. view all latest online Article 19 August 2020 OPEN ACCESS Prevention of dsRNA‐induced interferon signaling by AGO1x is linked to breast cancer cell proliferation Souvik Ghosh Joao C Guimaraes Manuela Lanzafame Alexander Schmidt Afzal Pasha Syed Beatrice Dimitriades Anastasiya Börsch Shreemoyee Ghosh Nitish Mittal Thomas Montavon Ana Luisa Correia Johannes Danner Gunter Meister Luigi M Terracciano Sébastien Pfeffer Salvatore Piscuoglio Mihaela Zavolan AGO1x, a translational readthrough isoform of Argonaute 1, localizes to the nucleus and interacts with proteins involved in dsRNA processing, promoting dsRNA clearance. Article 10 August 2020 OPEN ACCESS RNF43 truncations trap CK1 to drive niche‐independent self‐renewal in cancer Maureen Spit Nicola Fenderico Ingrid Jordens Tomasz Radaszkiewicz Rik GH Lindeboom Jeroen M Bugter Alba Cristobal Lars Ootes Max van Osch Eline Janssen Kim E Boonekamp Katerina Hanakova David Potesil Zbynek Zdrahal Sylvia F Boj Jan Paul Medema Vitezslav Bryja Bon‐Kyoung Koo Michiel Vermeulen Madelon M Maurice C‐te...